Surprisingly, 2 has actually an unusual, different binding form, because of the fluorine recognizing an H-bond from Leu83NH (Figure 3)
Surprisingly, 2 has actually an unusual, different binding form, because of the fluorine recognizing an H-bond from Leu83NH (Figure 3) To research whether either the bicyclic core or even the fluorophenyl party is responsible for the strange binding function, 3D-structures happened to be determined for two very early analogs of 2. both IP 3 plus …